Rare diseases · Sign or symptom
Lipoatrophy
Loss of fat tissue in localized area
HP:0100578
What it means
Localized loss of fat tissue.
This may occur as a result of subcutanous injections of insulin in the treatment of diabetes, from the use of human growth hormone or from subcutanous injections of Copaxone used for the treatment of multiple sclerosis. In the latter case, an injection may produce a small dent at the injection site. Lipoatrophy is also an adverse drug reaction that is associated with some antiretroviral drugs.
Rare diseases that can present with this34
Always100%
7Very common80–99%
19- Acquired partial lipodystrophy
- Acrogeria
- AREDYLD syndrome
- Atypical Werner syndrome
- Autosomal semi-dominant severe lipodystrophic laminopathy
- Becker nevus syndrome
- Ectodermal dysplasia, trichoodontoonychial type
- Familial partial lipodystrophy, Dunnigan type
- Familial partial lipodystrophy, Köbberling type
- Fucosidosis
- Lipodystrophy due to peptidic growth factors deficiency
- LMNA-related cardiocutaneous progeria syndrome
- Mandibuloacral dysplasia
- Microcephalic primordial dwarfism, Montreal type
- Neonatal Marfan syndrome
- Paternal 20q13.2q13.3 microdeletion syndrome
- Progeroid syndrome, Petty type
- Werner syndrome
- Wiedemann-Rautenstrauch syndrome
Common30–79%
3Sometimes5–29%
3The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Atrophy of fat · Loss of fat tissue in localised area
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.