Rare diseases · Sign or symptom
Limb muscle weakness
Limb weakness
HP:0003690
What it means
Reduced strength and weakness of the muscles of the arms and legs.
Rare diseases that can present with this19
Very common80–99%
2Common30–79%
11- Acute peripheral arterial occlusion
- Alexander disease type II
- Autosomal dominant progressive external ophthalmoplegia
- Bickerstaff brainstem encephalitis
- Childhood-onset nemaline myopathy
- Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome
- Dyggve-Melchior-Clausen disease
- Multifocal motor neuropathy
- Myasthenia gravis
- Progressive multifocal leukoencephalopathy
- Riboflavin transporter deficiency
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.