Rare diseases · Sign or symptom
Limb-girdle muscle weakness
HP:0003325
What it means
Weakness of the limb-girdle muscles (also known as the pelvic and shoulder girdles), that is, lack of strength of the muscles around the shoulders and the pelvis.
Rare diseases that can present with this20
Very common80–99%
3Common30–79%
10- Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency
- Alpha-B crystallin-related late-onset myopathy
- Autosomal dominant optic atrophy plus syndrome
- Bethlem muscular dystrophy
- Congenital muscular dystrophy with intellectual disability
- Congenital myasthenic syndrome with glycosylation defect
- Facioscapulohumeral dystrophy
- Oculopharyngeal muscular dystrophy
- Plectin-related limb-girdle muscular dystrophy R17
- Typical nemaline myopathy
Sometimes5–29%
6The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Limb girdle weakness · Muscle weakness, limb-girdle · Muscular weakness, limb-girdle
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.