Rare diseases · Sign or symptom
Lack of skin elasticity
HP:0100679
Rare diseases that can present with this18
Very common80–99%
14- 8q22.1microdeletion syndrome
- Acral self-healing collodion baby
- Atypical Werner syndrome
- Autosomal recessive cutis laxa type 1
- Autosomal recessive palmoplantar keratoderma and congenital alopecia
- Costello syndrome
- Huriez syndrome
- Lamellar ichthyosis
- Ledderhose disease
- Leri pleonosteosis
- Lipodystrophy due to peptidic growth factors deficiency
- Neu-Laxova syndrome
- Pseudoxanthoma elasticum
- Stiff skin syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tight skin
Lack of skin elasticity
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.