Rare diseases · Sign or symptom
Increased circulating interleukin 6 concentration
HP:0030783
What it means
The concentration of interleukin-6 in the blood circulation is above the upper limit of normal.
Rare diseases that can present with this14
Common30–79%
12- Acute lung injury
- Adult acute respiratory distress syndrome
- Castleman disease
- Familial hemophagocytic lymphohistiocytosis
- Giant cell arteritis
- Hemorrhagic fever-renal syndrome
- Infection-related hemolytic uremic syndrome
- Sepsis in premature infants
- Sweet syndrome
- TAFRO syndrome
- T-cell based immunotherapy-associated cytokine release syndrome
- Yellow fever
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Increased serum IL-6 · Increased serum interleukin-6
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.