Rare diseases · Sign or symptom
Abnormal circulating interleukin 6 concentration
HP:6000441
What it means
Any deviation from the normal range of the concentration of interleukin 6 (IL-6) in the blood circulation.
IL-6 is a pleiotropic cytokine with functions such as production of acute phase proteins in the liver, haematopoiesis, osteoclast activation, proliferation and differentiation of B lymphocytes and also the induction of fever in the brain. IL-6 behaves both as a cytokine and myokine in the immune system, affecting many auto-immune diseases. IL-6 is well-known for its effects in diabetes, atherosclerosis, prostate cancer, encephalitis and also rheumatoid arthritis, acting as a pro-inflammatory cytokine reinforcing the inflammatory states.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.