Increased circulating insulin-like growth factor 1 concentration

What it means

The concentration of insulin-like growth factor 1 (IGF1) in the blood circulation is above the upper limit of normal.

Growth hormone and IGF-I are important regulators of bone homeostasis throughout life. During the prepubertal period, GH and IGF-I are determinants of longitudinal bone growth, skeletal maturation, and acquisition of bone mass, whereas in adults they are important in the maintenance of bone mass.

Rare diseases that can present with this4

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Elevated serum IGF1 · Increased serum IGF1 · Increased serum insulin-like growth factor 1