Rare diseases · Sign or symptom
Increased bone mineral density
Increased bone density
HP:0011001
What it means
An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often referred to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones.
This term may be merged with Increased bone density in the future or made obsolete.
Rare diseases that can present with this39
Very common80–99%
21- Autosomal recessive hypophosphatemic rickets
- Beemer-Ertbruggen syndrome
- Blomstrand lethal chondrodysplasia
- Craniofacial dysostosis-diaphyseal hyperplasia syndrome
- Craniometadiaphyseal dysplasia, wormian bone type
- Dentin dysplasia
- Diastrophic dysplasia
- Dysosteosclerosis
- Dysplastic cortical hyperostosis, Kozlowski-Tsuruta type
- Erdheim-Chester disease
- Isolated osteopoikilosis
- Lenz-Majewski hyperostotic dysplasia
- Melorheostosis
- Osteomesopyknosis
- Osteopathia striata-cranial sclerosis syndrome
- Osteosclerosis-developmental delay-craniosynostosis syndrome
- Osteosclerosis-ichthyosis-premature ovarian failure syndrome
- Pycnodysostosis
- Schnitzler syndrome
- Sclerosteosis
- Spondyloepiphyseal dysplasia-craniosynostosis-cleft palate-cataracts-intellectual disability syndrome
Common30–79%
9The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Osteosclerosis · Osteosclerosis of bones
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.