Impaired specific antibody response

What it means

Reduced ability of the immune system to produce targeted, protective antibodies (immunoglobulins) against specific pathogens or vaccines in the setting of normal or near-normal serum levels of total IgG, IgA, and IgM and normal absolute counts of B cells and T cells.

Decreased circulating concentration of specific antibodies

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Abnormal specific antibody response · Decreased circulating level of specific antibodies · Decreased specific antibody in blood · Specific antibody deficiency