Rare diseases · Sign or symptom

Hyposegmentation of neutrophil nuclei

HP:0011447

What it means

Hyposegmented (hypolobulated) or bilobed neutrophil nuclei.

Hyposegmented cells are neutrophils with fewer than three nuclear lobes.

Rare diseases that can present with this2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Hyposegmentation of neutrophil nuclei in peripheral blood · Pelger-Huet anomaly

Hyposegmentation of neutrophil nuclei

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.