Rare diseases · Sign or symptom
Hypoalbuminemia
Low blood albumin
HP:0003073
What it means
The concentration of albumin in the blood circulation is below the lower limit of normal.
Rare diseases that can present with this53
Very common80–99%
10- Congenital analbuminemia
- Congenital enterocyte heparan sulfate deficiency
- Congenital lethal erythroderma
- Familial hemophagocytic lymphohistiocytosis
- Fibronectin glomerulopathy
- Idiopathic steroid-resistant nephrotic syndrome
- Macrophage activation syndrome
- MPI-CDG
- Neonatal intrahepatic cholestasis due to citrin deficiency
- S-adenosylhomocysteine hydrolase deficiency
Common30–79%
21- Abetalipoproteinemia
- Acute bilirubin encephalopathy
- ALG1-CDG
- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Chronic bilirubin encephalopathy
- Citrullinemia type II
- Eosinophilic gastroenteritis
- Glycogen storage disease due to glycogen branching enzyme deficiency
- Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance
- Insulin-resistance syndrome type B
- Juvenile polyposis of infancy
- Kawasaki disease
- Leishmaniasis
- Ménétrier disease
- Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders
- Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome
- Primary intestinal lymphangiectasia
- Refractory celiac disease
- Spinocerebellar ataxia with axonal neuropathy type 1
- Tropical endomyocardial fibrosis
- Wolcott-Rallison syndrome
Sometimes5–29%
20- AL amyloidosis
- ALG12-CDG
- ALG6-CDG
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Bacterial toxic-shock syndrome
- Congenital enterovirus infection
- Generalized pustular psoriasis
- Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1
and 12 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased albumin concentration · Decreased albumin level · Decreased albumin level in blood · Decreased circulating abumin concentration · Hypoalbuminaemia · Low albumin · Reduced albumin concentration · Reduced albumin level
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.