Rare diseases · Sign or symptom

Hyperglutamatemia

High blood glutamate levels

HP:0500149

What it means

Concentration of glutamate in the blood circulation above the upper limit of normal.

Under normal circumstances, plasma glutamate concentration is 5-100 microM/L, the whole blood concentration is 150-300 microM/L while in the brain's ECF it is only 0.3-2 microM/L. {xref="PMID:22949847"}

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Increased blood glutamate concentration · Increased level of L-glutamic acid in blood

Hyperglutamatemia

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.