Rare diseases · Sign or symptom

Hippocampal atrophy

HP:0410170

What it means

Partial or complete wasting (loss) of hippocampus tissue that was once present.

The hippocampus is part of the temporal cortex (albeit allocortex rather than neocortex).

Rare diseases that can present with this1

Common30–79%

1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Atrophy of the hippocampus · Degeneration of the hippocampus

Hippocampal atrophy

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.