Rare diseases · Sign or symptom
Generalized limb muscle atrophy
Generalized muscle wasting
HP:0009055
What it means
Generalized (unlocalized) atrophy affecting muscles of the limbs in both proximal and distal locations.
Rare diseases that can present with this9
Common30–79%
5- Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome
- Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect
- Autosomal recessive spastic paraplegia type 39
- Childhood-onset nemaline myopathy
- Delta-sarcoglycan-related limb-girdle muscular dystrophy R6
Sometimes5–29%
2The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Generalised limb muscle atrophy · Generalised muscle atrophy, proximal and distal · Generalised muscle wasting · Generalized muscle atrophy, proximal and distal
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.