Rare diseases · Sign or symptom
Generalized amyotrophy
Diffuse skeletal muscle wasting
HP:0003700
What it means
Generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles.
Rare diseases that can present with this20
Common30–79%
10- Adenylosuccinate synthetase-like 1-related distal myopathy
- Autosomal recessive centronuclear myopathy
- Autosomal recessive spastic paraplegia type 67
- Classic multiminicore myopathy
- Fetal akinesia deformation sequence
- Frontotemporal dementia with motor neuron disease
- Myoclonus-cerebellar ataxia-deafness syndrome
- Progressive external ophthalmoplegia-myopathy-emaciation syndrome
- Ullrich congenital muscular dystrophy
- WARS2-related combined oxidative phosphorylation defect
Sometimes5–29%
7The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Diffuse amyotrophy · Diffuse muscle atrophy · Diffuse muscle wasting · Generalised amyotrophy · Generalised muscle atrophy · Generalised muscle degeneration · Generalized muscle atrophy · Generalized muscle degeneration
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.