Rare diseases · Sign or symptom
Feeding difficulties in infancy
HP:0008872
What it means
Impaired feeding performance of an infant as manifested by difficulties such as weak and ineffective sucking, brief bursts of sucking, and falling asleep during sucking. There may be difficulties with chewing or maintaining attention.
Rare diseases that can present with this188
Very common80–99%
43- Acrocardiofacial syndrome
- Adenocarcinoma of the oesophagus and oesophagogastric junction
- Bainbridge-Ropers syndrome
- Bowen-Conradi syndrome
- Canavan disease
- Cardiofaciocutaneous syndrome
- Cataract-intellectual disability-hypogonadism syndrome
- Cerebrofacioarticular syndrome
- CHARGE syndrome
- COFS syndrome
- Costello syndrome
- Ectodermal dysplasia-intellectual disability-central nervous system malformation syndrome
- Encephalopathy due to sulfite oxidase deficiency
- Familial dysautonomia
- Freeman-Sheldon syndrome
- Glycogen storage disease due to acid maltase deficiency, infantile onset
- Hypophosphatasia
- Jacobsen syndrome
- Kagami-Ogata syndrome due to maternal 14q32.2 hypermethylation
- Maternal uniparental disomy of chromosome 20 syndrome
- Menke-Hennekam syndrome
- Menkes disease
- Moebius syndrome
- Multiple mitochondrial dysfunctions syndrome type 5
- Pemphigus vulgaris
- Phosphoserine aminotransferase deficiency, infantile/juvenile form
- PMP22-RAI1 contiguous gene duplication syndrome
- Prader-Willi syndrome
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Prader-Willi syndrome due to translocation
- PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation
- Pyruvate dehydrogenase deficiency
- Ring chromosome 1 syndrome
- Rubinstein-Taybi syndrome
- Severe neurodevelopmental disorder with feeding difficulties-stereotypic hand movement-bilateral cataract
- Silver-Russell syndrome due to a point mutation
- Smith-Lemli-Opitz syndrome
- Squamous cell carcinoma of the esophagus
- Stüve-Wiedemann syndrome
- Zellweger syndrome
Common30–79%
37- 1p36deletion syndrome
- 21q22.11q22.12microdeletion syndrome
- 48,XXYY syndrome
- 8q24.3microdeletion syndrome
- Acrofacial dysostosis, Catania type
- Allan-Herndon-Dudley syndrome
- Angelman syndrome due to imprinting defect in 15q11-q13
- Aortic arch interruption
- Apert syndrome
- Autism spectrum disorder due to AUTS2 deficiency
- Bohring-Opitz syndrome
- Borjeson-Forssman-Lehmann syndrome
- Christianson syndrome
- Cleft hard palate
- Cleft lip/palate
- Cockayne syndrome
- Coffin-Lowry syndrome
- Cohen syndrome
- Combined oxidative phosphorylation defect type 39
- Congenital hypothyroidism due to maternal intake of antithyroid drugs
- Cornelia de Lange syndrome
- Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
- Esophageal atresia
- Familial thyroid dyshormonogenesis
- Fumaric aciduria
- Gabriele-de Vries syndrome
- Gamma-aminobutyric acid transaminase deficiency
- Gaucher disease
- Glutathione synthetase deficiency
- Glycogen storage disease due to acid maltase deficiency
- GMS syndrome
- Hao-Fountain syndrome due to 16p13.2 microdeletion
- Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1
- Hypertrophic cardiomyopathy with kidney anomalies due to mitochondrial DNA mutation
- Hypothyroidism due to deficient transcription factors involved in pituitary development or function
- Idiopathic congenital hypothyroidism
- Inclusion body myositis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.