Rare diseases · Sign or symptom
Feeding difficulties
Feeding problems
HP:0011968
What it means
Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it.
Difficulties with eating and drinking, resulting in decreased oral nutrition
Rare diseases that can present with this289
Very common80–99%
53- 16p11.2p12.2microdeletion syndrome
- 19q13.11microdeletion syndrome
- 46,XY difference of sex development-adrenal insufficiency due to CYP11A1 deficiency
- 48,XYYY syndrome
- ALG3-CDG
- Alobar holoprosencephaly
- Amish lethal microcephaly
- Athyreosis
- Atypical Rett syndrome
- Autosomal recessive cutis laxa type 2, classic type
- Baraitser-Winter cerebrofrontofacial syndrome
- Coffin-Siris syndrome
- COG7-CDG
- Congenital myasthenic syndrome
- Crisponi syndrome
- Desmosterolosis
- DYRK1A-related intellectual disability syndrome
- DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
- Ear-patella-short stature syndrome
- FOXG1 syndrome
- FOXG1 syndrome due to 14q12 microdeletion
- Galactose epimerase deficiency
- Hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome
- Infantile systemic hyalinosis
- Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
- Intellectual disability syndrome due to a DYRK1A point mutation
- Isolated congenital hypoglossia/aglossia
- Kagami-Ogata syndrome
- Kagami-Ogata syndrome due to maternal 14q32.2 microdeletion
- Kagami-Ogata syndrome due to paternal uniparental disomy of chromosome 14
- Krabbe disease
- Lobar holoprosencephaly
- Mandibulofacial dysostosis-microcephaly syndrome
- Marden-Walker syndrome
- Maternal uniparental disomy of chromosome 9 syndrome
- Methylmalonic acidemia with homocystinuria
- Microgastria-limb reduction defect syndrome
- Midline interhemispheric variant of holoprosencephaly
- Monosomy 9q22.3 syndrome
- Neonatal Marfan syndrome
- Paternal 20q13.2q13.3 microdeletion syndrome
- PEHO syndrome
- Pitt-Hopkins syndrome
- Pontocerebellar hypoplasia type 2
- Presynaptic congenital myasthenic syndrome
- PYCR2-related microcephaly-progressive leukoencephalopathy
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Schaaf-Yang syndrome
- Semilobar holoprosencephaly
- Silver-Russell syndrome
- SSR4-CDG
- X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome
- X small rings syndrome
Common30–79%
25- 17q24.2microdeletion syndrome
- 2q32q33deletion syndrome
- 3-methylglutaconic aciduria-neonatal cataract-neurologic involvement-congenital neutropenia syndrome
- 3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form
- 3-phosphoserine phosphatase deficiency, infantile/juvenile form
- Acute bilirubin encephalopathy
- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- AHDC1-related intellectual disability-obstructive sleep apnea-mild dysmorphism syndrome
- Airway infantile hemangioma
- ALG11-CDG
- ALG12-CDG
- ALG6-CDG
- Angelman syndrome
- Angelman syndrome due to maternal 15q11q13 deletion
- Angelman syndrome due to paternal uniparental disomy of chromosome 15
- Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome
- Arachnodactyly-abnormal ossification-intellectual disability syndrome
- Aromatic L-amino acid decarboxylase deficiency
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Autosomal recessive dopa-responsive dystonia
- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Autosomal recessive polycystic kidney disease
- Beta-thalassemia major
- Bilateral generalized polymicrogyria
- Birk-Barel syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 2 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased oral intake · Poor feeding
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.