Rare diseases · Sign or symptom
Facial asymmetry
Asymmetry of face
HP:0000324
What it means
An abnormal difference between the left and right sides of the face.
Rare diseases that can present with this108
Very common80–99%
21- Aortic arch anomaly-facial dysmorphism-intellectual disability syndrome
- Axial mesodermal dysplasia spectrum
- Bencze syndrome
- Camptodactyly-joint contractures-facial skeletal defects syndrome
- Cleft lip/palate-deafness-sacral lipoma syndrome
- Deafness-craniofacial syndrome
- Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome
- Delayed speech-facial asymmetry-strabismus-ear lobe creases syndrome
- Epiphyseal dysplasia-hearing loss-dysmorphism syndrome
- Focal dermal hypoplasia
- Hemifacial hyperplasia
- Holoprosencephaly-craniosynostosis syndrome
- Isolated Klippel-Feil syndrome
- Maternal uniparental disomy of chromosome 9 syndrome
- Megalencephaly-capillary malformation-polymicrogyria syndrome
- Microcephaly-deafness-intellectual disability syndrome
- Multiple pterygium-malignant hyperthermia syndrome
- Oculoauriculovertebral spectrum with radial defects
- Progressive hemifacial atrophy
- Saethre-Chotzen syndrome
- Unilateral ocular duplication
Common30–79%
33- Apert syndrome
- Auriculocondylar syndrome
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Autosomal recessive multiple pterygium syndrome
- Camptodactyly syndrome, Guadalajara type 3
- CHARGE syndrome
- CLAPO syndrome
- CLOVES syndrome
- Congenital hydrocephalus
- Craniofrontonasal dysplasia
- Curry-Jones syndrome
- Distal duplication 15q syndrome
- Dysmorphism-short stature-deafness-difference of sex development syndrome
- Frontonasal dysplasia-bifid nose-upper limb anomalies syndrome
- Gabriele-de Vries syndrome
- Grant syndrome
- Hypertrichosis cubiti
- Isolated hemihyperplasia
- Jacobsen syndrome
- Johnson neuroectodermal syndrome
- Linear nevus sebaceus syndrome
- Melnick-Needles syndrome
- Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome
- Oculoauriculofrontonasal syndrome
- Orofaciodigital syndrome type 1
- Primary condylar hyperplasia
- SATB2-associated syndrome due to a pathogenic variant
- Severe microbrachycephaly-intellectual disability-athetoid cerebral palsy syndrome
- Van den Ende-Gupta syndrome
- Velo-facial-skeletal syndrome
- Wiedemann-Steiner syndrome
- X-linked dominant chondrodysplasia punctata
- X-linked intellectual disability, Snyder type
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Asymmetric facies · Asymmetry of right and left side of face · Crooked face · Unbalanced face · Unequal sides of face · Uneven face · Uneven sides of face · Unsymmetrical face
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.