Rare diseases · Sign or symptom
Exaggerated cupid's bow
Cupid bow upper lip
HP:0002263
What it means
More pronounced paramedian peaks and median notch of the Cupid's bow.
This may be associated with a Deep philtrum, but that finding should be coded separately.
Rare diseases that can present with this20
Very common80–99%
5Common30–79%
6Sometimes5–29%
9- 14q11.2microduplication syndrome
- 16p13.11microdeletion syndrome
- Alternating hemiplegia of childhood
- Autosomal recessive Robinow syndrome
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Kagami-Ogata syndrome due to maternal 14q32.2 microdeletion
- Multiple pterygium-malignant hyperthermia syndrome
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Cupid's bow, accentuated · Cupid-bow shaped upper lip · Prominent cupid-bow of upper lip
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.