Rare diseases · Sign or symptom
ERG: Reduced dark-adapted b-wave amplitude
HP:0007984
What it means
A dark-adapted bright flash electroretinogram in which the b-wave that is of markedly lower amplitude than the associated a-wave.
Flashes will elicit an a-wave with an initial negative deflection followed by a b-wave with positive deflection. This feature refers to a reduction in the amplitude primarily of the b-wave.
Rare diseases that can present with this5
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Electronegative ERG · Electroretinogram: reduced b-wave amplitude · Reduced amplitude of dark-adapted bright flash electroretinogram b-wave · Reduced electroretinogram rod b-wave · Reduced ERG amplitude of b-wave
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.