Rare diseases · Sign or symptom

Episodic paroxysmal anxiety

HP:0000740

What it means

Recurrent attacks of severe anxiety, which occur without restriction to any particular situation or set of circumstances, are therefore unpredictable.

An anxiety attack may manifest with one or more of the following symptoms: (i) difficulty breathing; (ii) palpitations; (iii) a feeling of unreality; (iv) pain or tightness in the chest; (v) trembling, dizziness, or feeling unsteady; (vi) sweating; (vii) a feeling of faintness; (viii) a fear of dying; (ix) a feeling of losing control; (x) tingling in hands and feet (paresthesia); (xi) choking or smothering feelings.

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Episodic paroxysmal anxiety

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.