Rare diseases · Sign or symptom

Epiphyseal stippling

Speckled calcifications in end part of bone

HP:0010655

What it means

The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses.

Stippling resolves with maturation of the epiphysis but is often replaced by some permanent epiphyseal abnormality.

Rare diseases that can present with this14

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Epiphyseal punctate calcifications · Stippled epiphyses · Stippling of the epiphyses

Epiphyseal stippling

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.