Rare diseases · Sign or symptom
Elevated circulating HDL-C concentration
High blood HDL level
HP:0012184
What it means
The concentration of high-density lipoprotein cholesterol in the blood circulation is above the upper limit of normal.
The major apolipoproteins of HDL are apolipoprotein (apo) A-I and apo A-II, also known as the alpha lipoproteins. Thus, hyperalphalipoproteinemia refers to an elevated concentration of apo A-I and apo A-II.
Rare diseases that can present with this2
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated high-density lipoprotein cholesterol concentration · Elevated high-density lipoprotein cholesterol level · Elevated high-density lipoprotein cholesterol level in blood · Hyperalphalipoproteinemia · Increased circulating high-density lipoprotein levels · Increased high-density lipoprotein cholesterol concentration · Increased high-density lipoprotein cholesterol level · Increased high-density lipoprotein cholesterol level in blood
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.