Rare diseases · Sign or symptom

Elevated circulating haptoglobin concentration

HP:0020180

What it means

The concentration of haptoglobin in the blood circulation is above the upper limit of normal.

Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation.

Rare diseases that can present with this2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Elevated haptoglobin concentration · Elevated haptoglobin level · Elevated haptoglobin level in blood · Increased haptoglobin concentration · Increased haptoglobin level · Increased haptoglobin level in blood

Elevated circulating haptoglobin…

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.