Rare diseases · Sign or symptom
Elevated circulating creatinine concentration
Elevated creatinine
HP:0003259
What it means
An increased amount of creatinine in the blood.
Rare diseases that can present with this29
Very common80–99%
5Common30–79%
11- ALECT2 amyloidosis
- C3 glomerulopathy
- Dopamine beta-hydroxylase deficiency
- Hereditary amyloidosis with primary renal involvement
- IgG4-related kidney disease
- IgG4-related retroperitoneal fibrosis
- Multiple myeloma
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
- Shiga toxin-associated hemolytic uremic syndrome
- Tubulointerstitial nephritis and uveitis syndrome
- Yellow fever
Sometimes5–29%
12- Acute interstitial pneumonia
- Bacterial toxic-shock syndrome
- Cardiogenic shock
- Diffuse alveolar hemorrhage
- Hypoxanthine guanine phosphoribosyltransferase partial deficiency
- Idiopathic non-lupus full-house nephropathy
- Immune-mediated thrombotic thrombocytopenic purpura
- Juvenile nephropathic cystinosis
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated serum creatinine · High blood creatinine level · Increased creatinine · Increased serum creatinine
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.