Rare diseases · Sign or symptom

Elevated circulating calprotectin concentration

HP:6000502

What it means

The concentration of calprotectin in the blood circulation is above the upper limit of normal.

Calprotectinis an acute-phase protein produced by monocytes and neutrophils in the circulation and inflamed tissues.

Rare diseases that can present with this1

Common30–79%

1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Elevated circulating calprotectin…

Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.

Start free with Eleplan

This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.