Rare diseases · Sign or symptom
Functional motor deficit
HP:0004302
Rare diseases that can present with this61
Very common80–99%
9- Atypical Rett syndrome
- Charcot-Marie-Tooth disease type 4C
- Epilepsy of infancy with migrating focal seizures
- Infantile Krabbe disease
- Progressive multifocal leukoencephalopathy
- Rasmussen syndrome
- Severe Canavan disease
- Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
- X-linked adrenoleukodystrophy
Common30–79%
24- Angelman syndrome due to maternal 15q11q13 deletion
- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Autosomal dominant spastic paraplegia type 4
- Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency
- Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency
- Bilateral polymicrogyria
- Cockayne syndrome type 3
- Cysticercosis
- Folinic acid-responsive seizures
- Gorham-Stout disease
- Infantile-onset axonal motor and sensory neuropathy-optic atrophy-neurodegenerative syndrome
- Japanese encephalitis
- Late-infantile/juvenile Krabbe disease
- Leukoencephalopathy with bilateral anterior temporal lobe cysts
- MFF-related encephalopathy due to mitochondrial and peroxisomal fission defect
- Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome
- Multifocal motor neuropathy
- Multiple osteochondromas
- New-onset refractory status epilepticus
- Pelizaeus-Merzbacher disease, connatal form
- Poliomyelitis
- Spinocerebellar ataxia type 40
- Subacute inflammatory demyelinating polyneuropathy
- X-linked cerebral adrenoleukodystrophy
Sometimes5–29%
23- Acquired aneurysmal subarachnoid hemorrhage
- Adrenomyeloneuropathy
- Adult Krabbe disease
- Adult-onset autosomal dominant leukodystrophy
- Atypical progressive supranuclear palsy syndrome
- Autosomal recessive complex spastic paraplegia due to Kennedy pathway dysfunction
- Bilateral frontal polymicrogyria
- Choreoacanthocytosis
and 15 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Functional motor problems
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.