Rare diseases · Sign or symptom
Dermal atrophy
Skin degeneration
HP:0004334
What it means
Partial or complete wasting (atrophy) of the skin.
Rare diseases that can present with this28
Very common80–99%
11- Acute radiation syndrome
- Exostoses-anetodermia-brachydactyly type E syndrome
- Flynn-Aird syndrome
- Hallermann-Streiff syndrome
- Hoyeraal-Hreidarsson syndrome
- Malignant atrophic papulosis
- Mandibuloacral dysplasia with type A lipodystrophy
- Mandibuloacral dysplasia with type B lipodystrophy
- Microphthalmia with linear skin defects syndrome
- Restrictive dermopathy
- Xeroderma pigmentosum-Cockayne syndrome complex
Common30–79%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Atrophic skin · Skin atrophy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.