Rare diseases · Sign or symptom

Deep white matter hypodensities

HP:0007321

What it means

Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter.

See also definition for "Periventricular white matter hypodensities". These two entities are in contra-distinction to each other.

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Deep cerebral white matter hypodensities

Deep white matter hypodensities

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.