Rare diseases · Sign or symptom

Decreased circulating ferritin concentration

Decreased serum ferritin

HP:0012343

What it means

Abnormally reduced concentration of ferritin, a ubiquitous intracellular protein that stores iron, in the blood.

Ferritin levels measured in serum usually have a direct correlation with the total amount of iron stored in the body, but ferritin levels may also be increased with anemia of chronic disease or in the course of an acute phase reaction.

Rare diseases that can present with this4

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Decreased plasma ferritin · Low ferritin level · Reduced serum ferritin

Decreased circulating ferritin…

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.