Rare diseases · Sign or symptom

Decreased circulating alkaline phosphatase activity

Decreased serum alkaline phosphatase

HP:0003282

What it means

Concentration or activity of alkaline phosphatase outside the upper or lower limtis of normal in the blood circulation.

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Low alkaline phosphatase · Low ALP

Decreased circulating alkaline…

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.