Rare diseases · Sign or symptom

Cutaneous cyst

Skin cyst

HP:0025245

What it means

A hollow mass located in the skin that is surrounded by an epithelium-lined wall and is well demarcated from the adjacent tissue. Cysts are often said to be sac-like and may contain serous liquid or semisolid material.

In contrast to cysts, vesicles, pustules and bullae do not have a complete epithelial lining and are therefore less well demarcated.

Rare diseases that can present with this3

Common30–79%

1

Sometimes5–29%

2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Cutaneous cyst

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.