Rare diseases · Sign or symptom

Cornea verticillata

HP:0500008

What it means

Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea.

Cornea verticillata can be a feature of Fabry disease and can occur as an adverse effect of mediciations including amiodarone. {xref="https://orcid.org/0000-0002-0736-9199"}

Rare diseases that can present with this2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Vortex keratopathy

Cornea verticillata

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.