Rare diseases · Sign or symptom
Coldness
HP:0033850
What it means
Relative coldness of a body part to palpitation, often acccompanied by feelings of coldness.
Coldness is a nonspecific finding, but can be a sing of peripheral vascular disease with a reduction in blood perfusion resulting in relative coldness of the affected body part (usually a hand or foot or an extremity).
Rare diseases that can present with this5
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Cold skin temperature · Cool skin · Cool skin temperature · Coolness to palpation
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.