Rare diseases · Sign or symptom
Chronic otitis media
Chronic infections of the middle ear
HP:0000389
What it means
Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear.
Rare diseases that can present with this44
Very common80–99%
11- 16p11.2p12.2microdeletion syndrome
- Autosomal non-syndromic agammaglobulinemia
- Combined immunodeficiency due to CRAC channel dysfunction
- Combined immunodeficiency due to DOCK8 deficiency
- Fragile X syndrome
- Mucopolysaccharidosis type 1
- Mucopolysaccharidosis type 3
- Mucopolysaccharidosis type 6
- Reticular dysgenesis
- Wiskott-Aldrich syndrome
- X-linked agammaglobulinemia
Common30–79%
21- 22q11.2deletion syndrome
- 48,XXXY syndrome
- 48,XXYY syndrome
- 49,XXXXY syndrome
- Alpha-mannosidosis
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Autosomal recessive Robinow syndrome
- Cleidocranial dysplasia
- Felty syndrome
- GATA2 deficiency spectrum
- Isolated cleft lip
- Kabuki syndrome
- Kleefstra syndrome
- PGM3-CDG
- Pierre-Robin sequence-Manzke dysostosis-clinodactyly of the index finger syndrome
- Primary ciliary dyskinesia
- Recombinant 8 syndrome
- Sotos syndrome
- Stickler syndrome
- Williams syndrome
- X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Chronic ear infection · Chronic middle ear infection · Otitis media, chronic
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.