Rare diseases · Sign or symptom

Calvarial hyperostosis

Overgrowth of skullcap

HP:0004490

What it means

Excessive growth of the calvaria.

The calvaria (skull cap) is made up of the frontal, occipital, right and left parietal, right and left temporal, sphenoid, and ethmoid bones, and thus comprises the upper dome-like part of the skull and does not include the lower jaw.

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Enlargement of calvarial bones · Excessive growth of calvarial bones · Hyperostosis of calvarial bones · Hypertrophy of calvarial bones · Increased ossification of calvarial bones · Overgrowth of calvarial bones · Thick calvarial bones

Calvarial hyperostosis

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.