Rare diseases · Sign or symptom
Calf muscle pseudohypertrophy
HP:0003707
What it means
Enlargement of the muscles of the calf due to their replacement by connective tissue or fat.
Pseudohypertrophy of the calf musculature is commonly seen in certain muscular dystrophies but also with spinal muscular atrophy and other denervating conditions.
Rare diseases that can present with this10
Common30–79%
7- Acquired generalized lipodystrophy
- Alpha-sarcoglycan-related limb-girdle muscular dystrophy R3
- Congenital muscular dystrophy with cerebellar involvement
- Distal myopathy, Tateyama type
- Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5
- ISPD-related limb-girdle muscular dystrophy R20
- Maternal uniparental disomy of chromosome 4 syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Pseudohypertrophy of the calves
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.