Rare diseases · Sign or symptom

Bilateral superior vena cava

HP:0033379

What it means

The presence of a left and a right superior vena cava.

The thoracic embryonic venous system is composed of two large veins (the superior cardinal veins) which return blood from cranial aspect of embryo, and the inferior cardinal vein, which returns blood from the caudal aspect. Both pairs of veins join to form right and left common cardinal veins before entering the embryological heart. The left common cardinal vein persists to form coronary sinus and oblique vein of left atrium. During the 8th week of gestation, an anastomosis forms between right and left superior cardinal veins resulting in the innominate (or brachiocephalic) vein. The cephalic portion of superior cardinal veins form the internal jugular veins. The caudal portion of right superior vein forms the normal right-sided superior vena cava, while the portion of the left superior cardinal vein caudal to the innominate vein normally regresses to become the ligament of Marshall. If this normal regression of the left superior cardinal vein fails to occur, a persistent left-sided vascular structure that empties into the coronary sinus, results (Persistent left superior vena cava or PLSVC). The innominate vein may or may not degenerate in these cases leading to variations in anatomy. The most common subtype of PLSVC results in the presence of both left and right SVCs (Bilateral SVC). A bridging innominate vein may or may not be present.

Part of the broader category

Also called: Bilateral SVC

Bilateral superior vena cava

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.