Rare diseases · Sign or symptom
Bifid scrotum
Cleft of scrotum
HP:0000048
What it means
Midline indentation or cleft of the scrotum.
A testis may or may not be present in each half of the scrotum.
Rare diseases that can present with this38
Very common80–99%
5Common30–79%
14- 20q11.2microduplication syndrome
- Autosomal dominant omodysplasia
- Autosomal dominant popliteal pterygium syndrome
- Brachytelephalangy-dysmorphism-Kallmann syndrome
- CHARGE syndrome
- Cryptomicrotia-brachydactyly-excess fingertip arch syndrome
- Cutis gyrata-acanthosis nigricans-craniosynostosis syndrome
- Deafness-intellectual disability syndrome, Martin-Probst type
- Fetal hydantoin syndrome
- Hypertelorism-hypospadias-polysyndactyly syndrome
- LUMBAR syndrome
- Ring chromosome 13 syndrome
- SCARF syndrome
- X-linked myotubular myopathy-abnormal genitalia syndrome
Sometimes5–29%
16- 19q13.11microdeletion syndrome
- 45,X/46,XY mixed gonadal dysgenesis
- 46,XY difference of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency
- Acrofrontofacionasal dysostosis
- Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- Duplication of urethra
- Exstrophy-epispadias complex
and 8 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Scrotal cleft
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.