Rare diseases · Sign or symptom
Areflexia of lower limbs
HP:0002522
What it means
Inability to elicit tendon reflexes in the lower limbs.
Rare diseases that can present with this12
Common30–79%
9- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal dominant optic atrophy and cataract
- Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome
- Charcot-Marie-Tooth disease type 1E
- Friedreich ataxia
- Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
- Myoclonus-cerebellar ataxia-deafness syndrome
- Spinocerebellar ataxia type 25
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Absent lower limb tendon reflexes · Areflexia in lower limbs · Areflexia of the lower limbs · Areflexia, lower limbs
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.