Anti-centromere antibody positivity

What it means

The presence of autoantibodies (immunoglobulins) in the serum that react against the centromeres or centromere components.

Anti-centromere antibodies are typically associated with pulmonary arterial hypertension and the limited cutaneous form of systemic sclerosis.

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: ACA positivity · Anticentromere antibody positivity