Rare diseases · Sign or symptom
Anterior pituitary hypoplasia
Underdeveloped pituitary gland
HP:0010627
What it means
Underdevelopment of the anterior pituitary gland.
Rare diseases that can present with this18
Very common80–99%
1Common30–79%
11- 14q22q23microdeletion syndrome
- ANE syndrome
- Combined pituitary hormone deficiencies, genetic forms
- Hypothyroidism due to deficient transcription factors involved in pituitary development or function
- Non-acquired panhypopituitarism
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Prader-Willi syndrome due to translocation
- Septo-optic dysplasia spectrum
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hypoplasia of the pituitary gland · Small anterior pituitary lobe
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.