Rare diseases · Sign or symptom
Amblyopia
Lazy eye
HP:0000646
What it means
Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways.
Ambylopia can result from visual deprivation during the critical period of development of visual abilities which lasts to about the age of 8 years. Thus, ambylopia can result from strabismus, anisometropia, or high hypermetropia in there is a failure to form a focused image in one or both eyes.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this53
Very common80–99%
5Common30–79%
12- Ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome
- Bencze syndrome
- Blepharophimosis-ptosis-epicanthus inversus syndrome plus
- Congenital fibrosis of extraocular muscles
- Hermansky-Pudlak syndrome
- Homocystinuria due to cystathionine beta-synthase deficiency
- Hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndrome
- Marcus-Gunn syndrome
- Marshall syndrome
- Non-syndromic unicoronal craniosynostosis
- Oculocutaneous albinism type 1
- Tetrasomy 9p syndrome
Sometimes5–29%
33- 19p13.3microduplication syndrome
- Angelman syndrome
- Axial spondylometaphyseal dysplasia
- Basel-Vanagaite-Smirin-Yosef syndrome
- Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome
- Congenital glaucoma
- Crouzon syndrome
- Down syndrome
and 25 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Wandering eye · Wandering eyes
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.