Rare diseases · Sign or symptom
Reduced visual acuity
Decreased clarity of vision
HP:0007663
Rare diseases that can present with this99
Very common80–99%
15- Åland Islands eye disease
- Autosomal dominant optic atrophy and cataract
- Axial spondylometaphyseal dysplasia
- Cogan syndrome
- Congenital stationary night blindness
- Dermochondrocorneal dystrophy
- Fuchs endothelial corneal dystrophy
- Herpes simplex virus stromal keratitis
- Isolated aniridia
- Oculocutaneous albinism type 1
- Oculocutaneous albinism type 4
- Oculocutaneous albinism type 6
- Persistent hyperplastic primary vitreous
- Sympathetic ophthalmia
- X-linked endothelial corneal dystrophy
Common30–79%
42- 8q24.3microdeletion syndrome
- Achromatopsia
- AGel amyloidosis
- Alport syndrome
- Autosomal dominant keratitis
- Autosomal recessive complex spastic paraplegia due to Kennedy pathway dysfunction
- Autosomal recessive spastic paraplegia type 55
- Bardet-Biedl syndrome
- Cancer-associated retinopathy
- Central areolar choroidal dystrophy
- Chédiak-Higashi syndrome
- Congenital hereditary endothelial dystrophy type II
- Danon disease
- Early-onset X-linked optic atrophy
- Familial exudative vitreoretinopathy
- Full NF2-related schwannomatosis
- Gelatinous drop-like corneal dystrophy
- Granular corneal dystrophy type II
- Idiopathic panuveitis
- Idiopathic uveal effusion syndrome
- Iridocorneal endothelial syndrome
- IRVAN syndrome
- Isolated succinate-CoQ reductase deficiency
- Limbal stem cell deficiency
- MEPAN syndrome
- Nance-Horan syndrome
- Oculocutaneous albinism type 2
- Optic atrophy-intellectual disability syndrome
- Optic pathway glioma
- Pituitary carcinoma
- Pituitary dermoid and epidermoid cysts
- Pontocerebellar hypoplasia type 2
- Primary hyperoxaluria
- Ramos-Arroyo syndrome
- Retinal cavernous hemangioma
- Severe early-childhood-onset retinal dystrophy
- Spinocerebellar ataxia type 25
- Spinocerebellar ataxia type 7
- Usher syndrome type 1
- Usher syndrome type 2
- Wagner disease
- Xq21microdeletion syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased central vision · Decreased visual acuity · Poor visual acuity
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.