Rare diseases · Sign or symptom
Agenesis of mandibular central incisor
HP:0006355
What it means
Agenesis of lower secondary incisor or lower primary incisor.
Rare diseases that can present with this1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Absence of lower central incisor · Absence of mandibular central incisor · Failure of development of mandibular central incisor · Missing lower central incisor · Missing mandibular central incisor
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.