Rare diseases · Sign or symptom
Adrenal hyperplasia
Enlarged adrenal glands
HP:0008221
What it means
Enlargement of the adrenal gland.
Rare diseases that can present with this12
Common30–79%
7- Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
- Congenital lipoid adrenal hyperplasia due to STAR deficency
- Cushing disease
- Cushing syndrome due to ectopic ACTH secretion
- Familial hyperaldosteronism type I
- Generalized glucocorticoid resistance syndrome
- Primary unilateral adrenal hyperplasia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Adrenal hyperplasia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.