Rare diseases · Sign or symptom
Adducted thumb
Inward turned thumb
HP:0001181
What it means
In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger.
The thumb is both flexed and adducted. Lesser degrees of adduction than that specified here may warrant the use of this term, for example, when the tip of the thumb lies near the base of F2 or F3.
Rare diseases that can present with this38
Very common80–99%
7Common30–79%
8- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Blepharophimosis-intellectual disability syndrome, Verloes type
- Christianson syndrome
- Congenital limbs-face contractures-hypotonia-developmental delay syndrome
- Hydrocephalus with stenosis of the aqueduct of Sylvius
- L1 syndrome
- Ullrich congenital muscular dystrophy
Sometimes5–29%
22- 20q11.2microdeletion syndrome
- 3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form
- ALG13-CDG
- Autosomal dominant cutis laxa
- Autosomal recessive myogenic arthrogryposis multiplex congenita
- Basel-Vanagaite-Smirin-Yosef syndrome
- COG7-CDG
- Galloway-Mowat syndrome
and 14 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Adducted thumbs · Thumb-in-palm deformity · Thumb-in-palm pattern
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.