Rare diseases · Sign or symptom
Acral blistering
HP:0031045
What it means
Bullae (defined as fluid-filled blisters more than 5 mm in diameter with thin walls) of the skin with an acral distribution (affecting peripheral regions such as hands and feet).
Rare diseases that can present with this6
Common30–79%
5- Autosomal dominant generalized dystrophic epidermolysis bullosa
- Epidermolysis bullosa simplex with circinate migratory erythema
- Localized dystrophic epidermolysis bullosa, acral form
- Localized junctional epidermolysis bullosa
- PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.