Rare diseases · Sign or symptom
Abnormal naive CD4+ T cell proportion
HP:0410373
What it means
Abnormal increase or decrease of the naive CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
Rare diseases that can present with this1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Abnormal naive CD4-positive T cell proportion · Abnormal proportion of CD4+CD45RA+ cells · Abnormal proportion of naive CD4 T cells · Abnormal proportion of naive CD4+ T cells · Abnormal proportion of naive thymus-derived CD4-positive, alpha-beta T cells
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.