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Rare diseases · Sign or symptom

Abnormal memory B cell proportion

HP:0030373

What it means

A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).

Memory B cells can be defined as CD19+/CD27+ or CD20+/CD27+ cells in flow cytometry.

Part of the broader category

Abnormal B cell subset distribution

Also called: Abnormal proportion of memory B cells

Abnormal memory B cell proportion

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.